"The cops WILL show up."

This is the optimized path for completing the heroin run.

Introduction

Before starting this run, it is strongly recommended to check the price of black heroin for optimal profits and to follow the list below to make sure you have all the required equipment.

Food and Water
Bergen Backpack for space
A vehicle to store the heroin
Heroin processing license ($25,000 at the processor)
Head to the Heroin Field east of Pygros to fill your vehicle and optionally your backpack using left windows key in the heroin field area

Starting the Run

Head southwest of the heroin field to the heroin processor to turn your goods into black heroin.
To process, scroll wheel on the NPC inside of the house, you can either process from the vehicle or from your backpack and must remain within 25m of the NPC.
Before pressing Process, it will give you the time required to process. Canceling processing will process items up to the progress you obtained.

Processing Heroin

Head southwest of the heroin field to the heroin processor to turn your goods into black heroin.
To process, scroll wheel on the NPC inside of the house, you can either process from the vehicle or from your backpack and must remain within 25m of the NPC.
Before pressing Process, it will give you the time required to process. Canceling processing will process items up to the progress you obtained.

Processing Pure Heroin

After turning your unprocessed heroin into black heroin, you will get the option to “Double Process” to turn it into pure heroin.
Turning black heroin into pure heroin increases your profits once sold (x1.25 current price).

Selling

After finishing processing take your vehicle to any Drug Dealer. The closest to heroin proccesor is to the west of Pygros.
Scroll wheel on the drug dealer to sell your heroin on your person, you will need to manually remove the drugs from the vehicle to sell.
When finished selling go to any ATM the closest being in DP 21 to store the money via scroll wheel or left windows key on the ATM.

Payout

The average payout for a heroin run using a Box Truck and a Bergen (210 heroin) is $640,080 for heroin and $720,090 for pure heroin. If your gang is in control of the cartel it will allow you to hold onto 15% more of the profits which is otherwise paid as gang tax to the controlling gang

Run Time

Using a tier 4 box truck the run took 35 minutes and 16 seconds. The alternate route posted above will be 31 minutes. If one was to double process it would take 41 minutes